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Our in vitro outcomes advise that EAM-2201 ought to be examined with regard to possible in vivo pharmacokinetic drug–drug interactions caused by time-dependent inhibition of CYP2C8, CYP2C9, CYP2C19 and CYP3A4 pursuits and aggressive inhibition of UGT1A3 exercise.
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Our in vitro results advise that EAM-2201 needs to be examined in terms of possible in vivo pharmacokinetic drug–drug interactions because of time-dependent inhibition of CYP2C8, CYP2C9, CYP2C19 and CYP3A4 activities and aggressive inhibition of UGT1A3 exercise.
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Then, the inhibitor focus that supports 50 % the maximal rate of inhibition (Ki) and maximal price of enzyme inhibition (kinact) values had been calculated employing the following equation with Soda Ash Producer Enzyme Kinetics software program:
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